The Library
Knowledge Base & Open Reference
This library is a comprehensive, open-access reference on the biology of aging and the science of longevity intervention. Every article is written to be read in full, cited where possible, and cross-linked to its dependencies. The goal is not to summarize what is known, but to make what is known accessible, precise, and interconnected. Nothing here is medical advice. Everything here is a map.
Foundations
Cellular Biology
- NAD+ Biology & Metabolismbiosynthesis · salvage pathway · precursors
- Autophagy: Cellular Self-Cleaningmacroautophagy · CMA · mitophagy
- Cellular Senescence & the SASPirreversible arrest · paracrine aging
- Mitochondrial Function & BiogenesisETC · ROS · PGC-1α
- Telomere Biology & Maintenancetelomerase · shelterin · ALT
- Stem Cell Exhaustion & Regenerationniche signaling · asymmetric division
- Proteostasis & Protein Quality Controlchaperones · UPS · aggregation
Molecular Pathways
- The mTOR PathwaymTORC1 · mTORC2 · nutrient sensing
- AMPK & Energy Sensingcellular energy gauge · metformin target
- Sirtuin Biology & Epigenetic RegulationSIRT1–7 · NAD+ dependency · deacetylation
- Insulin/IGF-1 Signaling & Longevitydaf-2 · growth hormone axis
- NF-κB & Inflammatory Cascadesinflammaging · cytokine storms
- Epigenetic Reprogramming & Yamanaka FactorsOSKM · partial reprogramming · age reversal
- DNA Damage & Repair MechanismsDSBs · BER · genomic instability
Interventions
- Rapamycin & RapalogsmTORC1 inhibition · ITP results · dosing
- Senolytic Therapydasatinib+quercetin · fisetin · navitoclax
- NAD+ Precursors: NMN, NR & Niacinsupplementation · bioavailability · trials
- Metformin & the TAME TrialAMPK activation · diabetes crossover
- Caloric Restriction & FastingCR mimetics · IF · time-restricted eating
- Exercise Physiology & Longevityzone 2 · VO2max · resistance training
- Sleep Architecture & Healthspanglymphatic system · circadian biology
- Hormesis & Adaptive Stresscold exposure · heat shock · xenohormesis
- Geroprotectors & Nutraceuticalsresveratrol · spermidine · urolithin A
Measurement & Biomarkers
- Epigenetic ClocksHorvath · GrimAge · DunedinPACE
- Blood Biomarkers of AgingCRP · IGF-1 · GDF-15 · cystatin C
- Wearable Biometrics & HRVOura · Whoop · continuous glucose
- Functional Assessments of Aginggrip strength · gait speed · VO2max
- Multi-Omics Approaches to Agingtranscriptomics · proteomics · metabolomics
Context
- Key Researchers & LaboratoriesSinclair · Barzilai · Campisi · Kenyon
- Clinical Trials in LongevityTAME · PEARL · dog aging project
- The Longevity Biotech LandscapeAltos · Calico · Unity · NewLimit
- Ethics of Life Extensionaccess · inequality · overpopulation
- Model Organisms in Aging ResearchC. elegans · mice · naked mole-rats
Resources
This library is continuously expanded. Each article is written for depth, not brevity. Cross-references are bidirectional. If a link appears, a page exists. If a claim appears, a citation follows.